Board-Certified Bariatric Surgeon. Founder of Sano Longevity. Speaker at Longevity Fest 2025
For more than ten years, Dr. Meredith Sweeney operated on the consequences of metabolic disease. Today she runs a longevity practice in Louisville built on a single conviction: 90% of aging is in our control. Treat your body well now and it will treat you well for decades to come.
Limited new patient appointments each month. No obligation. HSA and FSA eligible.
Board-certified bariatric surgeon, A4M member, founder of Sano Longevity in Middletown. Last updated July 2026.
Dr. Sweeney did not arrive at longevity medicine from a wellness conference. She arrived from inside other people’s abdomens.
For more than ten years she was a board-certified bariatric surgeon at Norton Healthcare in Louisville, performing the operations that treat the consequences of metabolic disease after every other intervention has failed. She saw, with the naked eye, what almost no other physician in the country sees on a daily basis.
"I could see the consequences of metabolic dysfunction. Yellow droplets and big dilated livers because of all the sugar stored there. I had to physically lift up livers that were sometimes so heavy we had to insert two retractors into the abdomen. Purely because of metabolic dysfunction."
That image is the difference between a longevity doctor who learned this from a textbook and a longevity doctor who learned it with her hands. No conference can teach you what a fatty liver feels like under your fingers. No supplement company can show you what visceral fat looks like when you are looking at it directly. Dr. Sweeney did not need a study to convince her that metabolic disease was the central problem. She had been operating on it for years.
The shift started in 2018. While still operating full-time at Norton, she began going to conferences on low-carb medicine, metabolic health, and the science of preventing the disease she was operating on. She bought textbooks. She read journals. She built a clinical education in nutrition and metabolic medicine that no formal residency program had given her.
And then she did something most surgeons never do. She rewrote the preoperative and postoperative diet protocols at her own hospital. With no formal nutrition degree aside from the one class in medical school. Because nobody else was going to do it, and her patients needed it. She watched her bariatric patients recover faster, hold their results longer, and avoid the complications that the old protocols allowed. The data on her own surgical caseload validated the approach. She kept building.
Most longevity doctors describe their experience in years. Dr. Sweeney’s experience is best described in patients, surgeries, and operating-room hours. Here are the numbers.
amount of bariatric surgeries performed (2014-2024)
Bariatric surgery patients managed
Of her clinical time at Norton spent outside the operating room, managing the lifestyle and metabolic health of her surgical patients
Sano Longevity patients evaluated since opening in March 2025
Unlike most longevity practices, Sano was founded by a surgeon who has operated on the consequences of metabolic dysfunction thousands of times.
"We start where you actually are, not where a protocol says you should be. Your plan is built around your data, your life, and what your body actually needs right now. Every plan is different because every patient is different. We meet you exactly where you are."
Dr. Sweeney’s philosophy is that nutrition, movement, stress, and sleep are not lifestyle suggestions. They are the four spokes of a wheel that does not turn if any one of them is missing. She measures every spoke before she touches a hormone, prescribes a medication, or recommends a supplement. She also knows that perfection is not the goal.
This is what makes her clinically different. Most longevity practices sequence labs, then hormones, then supplements, and never address the four pillars at all. Dr. Sweeney sequences the four pillars first, measures everything that drives them, and then layers in the hormones, peptides, and prescription medicine when the foundation is in place. Order matters. Doing it backwards is why most longevity protocols fail.
"Longevity medicine is not only about adding years to someone's life, it's about adding more life to their years."
Dr. Sweeney runs a 46-marker metabolic panel (subject to change) through Quest Diagnostics on every new Sano patient. She is not interested in collecting hundreds of useless labs as a marketing claim. She is interested in the markers that change outcomes. In her first 200+ Sano patients, three patterns have repeated themselves with alarming consistency.
Fasting insulin is a marker of metabolic dysfunction that primary care almost never tests, because insurance does not reimburse it as a screening test. Elevated fasting insulin predicts type 2 diabetes, fatty liver disease, and cardiovascular events years before any of them appear on a standard panel.
Standard labs say an Omega-3 index above 5% is fine. Longevity-grade research says you want to be above 8%. In Dr. Sweeney's first 200+ Sano patients, almost nobody walked in above 3%. The Omega-3 index is one of the most actionable longevity markers in modern blood work, and almost nobody is measuring
"Hormones are a piece of it, but unless you address your lifestyle first, hormones will not work well. "
This is the clinical assertion that separates Sano from the hormone-optimization clinics that dominate the longevity space. Hormones matter. Cortisol matters. But interpreting them from a single timepoint draw, with no diurnal rhythm context, is medicine that does not understand its own labs.
"I am going to identify the things leading you toward premature dementia, bone fractures, metabolic dysfunction, diabetes, heart disease, kidney disease. Years ahead of time."
Sano Longevity is a membership practice, not a single-visit clinic. The results compound over time. Small changes in the first quarter become measurable shifts by the second. Measurable shifts become real outcomes by the end of the year. The patients who stay the longest see the most.
Anchor Shannon Cogan visited Sano Longevity to get her biological age tested on the PNOĒ platform. The segment aired on WAVE Sunrise.
Dr. Sweeney spoke at Longevity Fest in December 2025, the largest annual longevity medicine conference in the United States, organized by the American Academy of Anti-Aging Medicine.
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Dr. Sweeney sees a limited number of new patients each month. The first call is free, takes 30 minutes, and is the right place to figure out whether Sano Longevity is the right fit before you commit.
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Founder, Sano Longevity in Middletown, Louisville. Board-certified bariatric surgeon. Fellow of the American College of Surgeons (FACS) and formerly the American Society for Metabolic and Bariatric Surgery (FASMBS). Member, American Academy of Anti-Aging Medicine (A4M). Speaker, Longevity Fest 2025. More than ten years of metabolic medicine experience at Norton Healthcare before founding Sano Longevity in March 2025.
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